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Direct Research Journals
Direct Research Journal of Health and Pharmacology (DRJHP):Vol.5 (2), pp. 7-13, October 2017
ISSN 2449-0814

Clinical Use of Pentraxin 3: A Review
Article Number: DRJA38706272
DOI: https://doi.org/10.26765/DRJHP.2017.6272

Review


Ali Kemal Erenler1*, Oğuzhan Yücel2 and Ahmet Baydın3


1Hitit University Çorum Education and Research Hospital, Çorum, Turkey.

2Samsun Education and Research Hospital, Samsun, Turkey.

3Samsun Ondokuzmayıs University, Samsun, Turkey.

*Corresponding author E-mail: akerenler@hotmail.com.


date Received: September 10, 2017     date Accepted: September 29, 2017     date Published: October 6, 2017

Abstract

Pentraxin 3 (PTX3) is a novel marker of the acute-phase inflammatory response, belonging to the PTX protein family. It also plays a role in innate immunity. It is known to be produced at the site of infection or inflammation by macrophages, monocytes, denditic cells and tissue cells. Increased levels of PTX3 in the circulating blood have been found to be involved in many pathologies such as coronary artery, respiratory system, renal, hematological, neurological and inflammatory diseases. In this review, we aimed to clarify the biochemical structure of PTX3 and reveal its etiological and diagnostic importance in diseases frequently seen in the Emergency Department.


Key words: Pentraxin, critical care, emergency medicine