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Direct Research Journals
Vol. 2 (1), pp. 1-7, February 2017
International Standard Journal Number ISJN: A4372-2601

The application of acute phase protein as biomarkers in bovine mastitis
Article Number: DRJA30873667


Asinamai Athliamai Bitrus1*, Babagana Mohammed Adam3, Dauda Mohammed Goni2,3, Peter Anjili Mshelia4,  Ibrahim Muhammad Jalo 3, Innocent Thlama Mshelia4 and  Idris Ibrahim Fika3

1Department of Veterinary Pathology and Microbiology, Faculty of Veterinary Medicine, Universiti Putra Malaysia, 43400 UPM Serdang Selangor Malaysia.

2Unit of Biostatistics and Research Methodology, School of Medical Sciences, Health Campus, Universiti Sains Malaysia, 16150 Kubang Kerian, Kelantan, Malaysia.

3Ministry of Agriculture and Natural Resources, Damaturu, Yobe State Nigeria.

4Department of physiology and biochemistry, Faculty of Veterinary Medicine, University of Maiduguri, P.M.B 1069 Maiduguri, Borno Nigeria.

*Corresponding author E-mail:

date Received: January 7, 2017     date Accepted: February 12, 2017     date Published: February 23, 2017


Acute phase proteins (APP) are components of the blood that plays a very significant role in maintaining or restoring homeostasis and inhibiting microbial growth in animal prior to the development of antibodies by the host during trauma, inflammation or infection process.  The concentration of circulating APP in the blood is directly related to the degree and or severity of disease and the extent of tissue damage. Additionally, it is also useful in monitoring response to disease, in disease diagnosis, prognosis and general health screening and evaluation. Acute phase proteins are classified according to concentration of protein, mode of action and concentration in other animals. The description of APP in cases of disease will help in mapping out a profile of APP characteristics of that disease, thus providing valuable information with regards to the mechanism of the disease process and also serves as a very good diagnostic aid. This review focuses on the role of APP in determining the type of mastitis, severity of mastitis and determinant of herd health.

Key Words: Acute phase proteins, Bovine, Haptoglobulin, Mastitis, Serum Amyloid.