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Effects of Aqueous Leaf Extract of Cola acuminata on Parasitaemia, Haematological and Liver Function Parameters in Plasmodium berghei Infected Mice
Article Number: DRJA36620589
Original Research Article
H. A. Zailani*, M. Banyawa and A. A. Muhammad
Department of Biochemistry, Modibbo Adama University of Technology,Yola, Adamawa State, Nigeria.
*Corresponding author Email:firstname.lastname@example.org
Received: April 11, 2016 Accepted: April 28, 2016 Published: May 3, 2016
Evaluation of the antimalarial activity of the aqueous leaf extract of Cola acuminata was carried out on mice infected with Plasmodium berghei. Six groups of 10 mice each were used. Groups D, E and F were treated with 50, 150 and 250 mg/Kg body weight of the extract respectively. Group C was treated with 20mg/Kg body weight chloroquine. Groups A and B served as controls. Treatment commenced 3 days after inoculation and lasted 3 days; and 7 days after inoculation, 6 mice from each group were sacrificed; liver function and haematological indices were evaluated. Tail blood was collected from the remaining animals on days 7, 9, 11 and 13 after inoculation for evaluation of parasitaemia. The extract contains alkaloids, phenolics, tannins, flavonoids, saponins, glycosides and terpenoids. Treatment significantly reduced (p<0.05) parasitaemia comparing favourably with chloroquine at the highest dose. Infection caused a significant decrease (p<0.05) in packed cell volume, haemoglobin, red blood cells, platelets, total protein, and the activity of alkaline phosphatase but caused a significant increase (p<0.05) in mean corpuscular volume, mean corpuscular haemoglobin, mean corpuscular haemoglobin concentration, white blood cells Â and neutrophils and activities of aspartate transaminase and alanine transaminase. These were ameliorated by treatment. Leaves of Cola acuminata possess good potentials as antimalarial remedy and improves some of the complications of malaria infection.
Key words: Cola acuminata, Plasmodium berghei, antimalarial, haematological indices, liver function indices.
Manuscript Reviewed by:
1. Dr. Appalanaidu Pappala
Department of Anthropology, Andhra University, Visakhapatnam-530003
2. Dr. Raquel Tostes
PÃ³s-graduaÃ§Ã£o em CiÃªncias VeterinÃ¡rias, Instituto de VeterinÃ¡ria, Universidade Federal Rural do Rio de Janeiro,Â SeropÃ©dica 23890-000, Rio de Janeiro, Brazil