Original Research Article
Article Number: DRJCMS17313205
Vol. 11(2), Pp. 18-22, February 2023
Copyright © 2023
Author(s) retain the copyright of this article
This article is published under the terms of the
Creative Commons Attribution License 4.0.
The aim of this research is to assess the lung histoarchitecture of wistar albino rats that inhaled Tusa-Tusa , a local insecticide. A total of 25 rats were randomly divided into 5 groups labeled A, B, C, D and E. They were kept in a well-ventilated room. Group A served as control and these rats were treated with distilled water. Rats in the groups B, C, D and E were treated with 5, 10, 15 and 20mL/Kgbw respectively. The drugs were inhaled once daily for five minutes. This was done for 7(short-term) and 14 (long-term) days consecutively. Animals were sacrificed 24 hours after the last treatment. The lungs of these animals were sent for histological studies. Distortions in lung histo-architecture were seen amongst the 20ml/Kgbw dose of the short-term group. The 5Kgbw dose of the long-term group showed normal cardiac musculature. The other doses showed abnormalities such as thickened interalveolar spaces and collapsed alveolar sacs. These were more prominent with higher doses of the local insecticide administered.
Keywords: Tusa-tusa local insecticide DDVP kerosene lungs