Myocardial Changes seen in the Hearts of Wistar Albino Rats Exposed to Inhaled Local Insecticide (Tusa-Tusa) Myocardial Changes seen in the Hearts of Wistar Albino Rats Exposed to Inhaled Local Insecticide (Tusa-Tusa) – Direct Research Journal of Chemistry and Material Science
Original Research Article

Myocardial Changes seen in the Hearts of Wistar Albino Rats Exposed to Inhaled Local Insecticide (Tusa-Tusa)

Oforibika, G. A.

Chioma Don-Lawson

Reminus Okah

Article Number: DRJCMS16292264
DOI: https://doi.org/10.26765/DRJCMS16292264
ISSN: 2354-4163

Vol. 11(3), Pp. 23-26, April 2023

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Creative Commons Attribution License 4.0.


Abstract

The purpose of this study is to examine the myocardium of wistar albino rats that were exposed to Tusa-Tusa, a local insecticide. A total of 25 rats were randomly assigned to one of five groups labeled A, B, C, D, or E. They were housed in a well-ventilated area. The rats in Group A were treated with distilled water as a control. Rats in groups B, C, D, and E were given doses of 5, 10, 15, and 20ml/Kgbw, respectively. For five minutes, the drugs were inhaled once per day. For 7 (acute) and 14 (chronic) consecutive days, this was done. 24 hours following the last treatment, animals were sacrificed.  These animals’ hearts were sent for histological analysis. The acute group receiving the 20ml/Kgbw dose had abnormal cardiac musculature. The chronic group’s lowest doses (5 and 10ml/Kgbw) revealed normal cardiac musculature. The anomalies got worse for the rest of the chronic group as the local pesticide dose got stronger.

Keywords: Heart Tusa-tusa Local insecticide Nigeria
 Received: January 8, 2023  Accepted: March 27, 2023  Published: April 3, 2023



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