Preparation, Experimental Characterization and Antimicrobial Studies of (E)-2-(((2-hydroxynaphthalen-1-yl) methylene) amino)-6-methylpyrimidin-4-ol and its Transition Metal Complexes

Abstract

The novel Schiff base (E)-2-(((2-hydroxynaphthalen-1-yl) methylene) amino)-6-methylpyrimidin-4-ol and its metallic chelates [M(L)₂(Y)_n]∙nH₂O [M=Mn²⁺, Fe²⁺, Co²⁺, Ni²⁺, plus Zn²⁺; L=Schiff base; Y=H₂O and n=0,1,2) have been synthesized and characterized via analytical (CHNS, melting point, solubility, magnetic and conductivity) methods, spectroscopic (FT-IR, UV-Vis, and H-1 and C-13NMR) plus magnetic susceptibility (µeff) measurements. The Uv-vis spectral analysis plus µeff   indicate a 6-coordinate octahedral assemblage for the Co²⁺ and Fe²⁺ chelates, a 4-coordinate tetrahedral assemblage for Mn²⁺ and Zn²⁺ and square planar assemblage for Ni²⁺ and Cu²⁺ chelates.  The low molar conductance values of the chelates in dimethyl-formamide ((CH₃)₂NC(O)H) corroborated their neutrality. The synthesized Schiff base and its metal chelates demonstrated modest to good activity against selected microorganisms.