Article Number: DRJHP16837191

DOI: https://doi.org/10.5281/zenodo.3374000

ISSN: 2449-0814

Vol.7 (4), pp. 38-42, August 2019

Copyright © 2019

Author(s) retain the copyright of this article


Original Research Article

Pharmacological evidence favouring the ethnomedicinal use of Luffa cylindrica (L.)  Roem leaf in the relief of pain and fever

*Saliu, O. A.

Akanji, M. A.

Idowu, O. A.

Saliu, N. B.


Abstract

A study to investigate the ethnobotanical use of Luffa cylindrica (L.) Roem leaf in pain and fever relief was carried out. Methanolic extract was obtained from leaves of Luffa cylindrica and was subjected to phytochemical screening using standard procedure of Trease and Evans, (1989). Analgesic effect of the plant was carried out by inducing pain in mice in the form of abdominal constriction using glacial acetic acid. The antipyretic property of the plant was also investigated in rats by yeast-induced pyrexia. Phytochemical analysis of methanolic extract of L. cylindrica leaves revealed the presence of saponins, tannins, phenolics, alkaloids, triterpenes, flavonoids and cardiac glycosides in appreciable amounts. The extract showed a significant (p < 0.05) inhibition of abdominal constriction in mice induced with pain sensation in a dose-dependent manner. Antipyretic activity of the plant was evident by a significant reduction (p < 0.05) in rectal temperature at all investigated doses (100, 200 and 400 mg/kg body weight) and was time dependent. Methanolic extract of Luffa cylindrica leaves exhibited potent analgesic and antipyretic activities which therefore supports the ethnopharmacological use of the plant.


Keywords: Luffa cylindrica, acetic acid, acetylsalicyclic acid, paracetamol, methanol


 Received: July 30, 2019  Accepted: August 14, 2019  Published: August 30, 2019

Saliu Et Al


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