Article Number: DRJHP18392132
Vol.8 (2), pp. 14-18, February 2020
Copyright © 2020
Author(s) retain the copyright of this article
Original Research Article
The assessment of effect of apple cider vinegar on hepatic and renal function of albino Wistar rat
The aim of this research is to investigate the toxic effect of apple cider vinegar on hepatic and renal function of albino Wistar rats. A total of 22 rats were randomly divided into 5 groups labeled A, B, C, D, and E and kept in a well-ventilated room. Group A served as control and these rats were treated with distilled water. Rats in groups B and C were treated with 2 different doses (1 ml and 2 ml respectively) for 7 days. Rats in groups D and E were treated with 2 different doses (1 ml and 2 ml respectively) for 14 days. The drugs were administered once daily. Animals were sacrificed 24 h after the last treatment. Blood samples were collected into heparinized sample bottles for analysis. There was no significant difference in the serum liver enzymes results obtained when compared to control. There were deaths in both 7 and 14 days of administration. The deaths were higher in those given 2 ml irrespective of duration. Pathological changes in the liver and kidney progressively increased with concentration and duration. This study demonstrates that large amounts of apple cider vinegar when used undiluted has negative effects on the liver and kidney.
Keywords: Apple cider vinegar, renal function, albino Wistar rats, serum liver enzymes