Article Number: DRJHP18392132

DOI: https://doi.org/10.26765/DRJHP18392132

ISSN: 2449-0814

Vol.8 (2), pp. 14-18, February 2020

Copyright © 2020

Author(s) retain the copyright of this article


Original Research Article

The assessment of effect of apple cider vinegar on hepatic and renal function of albino Wistar rat

George Adieboye Oforibika*

Udeme Jude Ogoloma


Abstract

The aim of this research is to investigate the toxic effect of apple cider vinegar on hepatic and renal function of albino Wistar rats. A total of 22 rats were randomly divided into 5 groups labeled A, B, C, D, and E and kept in a well-ventilated room.  Group A served as control and these rats were treated with distilled water. Rats in groups B and C were treated with 2 different doses (1 ml and 2 ml respectively) for 7 days. Rats in groups D and E were treated with 2 different doses (1 ml and 2 ml respectively) for 14 days. The drugs were administered once daily. Animals were sacrificed 24 h after the last treatment. Blood samples were collected into heparinized sample bottles for analysis. There was no significant difference in the serum liver enzymes results obtained when compared to control. There were deaths in both 7 and 14 days of administration. The deaths were higher in those given 2 ml irrespective of duration. Pathological changes in the liver and kidney progressively increased with concentration and duration. This study demonstrates that large amounts of apple cider vinegar when used undiluted has negative effects on the liver and kidney.


Keywords: Apple cider vinegar, renal function, albino Wistar rats, serum liver enzymes

 


 Received: January 13, 2020  Accepted: February 19, 2020  Published: February 28, 2020

Oforibika And Ogoloma1


Copyright © 2020 Direct Research Journal of Health and Pharmacology