Study of the renal function of Wistar albino rat treated with three different herbal bitters (Confam, G. Winco and 1960 Roots)

Abstract

This study evaluates the renal function of Wistar albino rats treated with three different herbal bitters (confam, G.Winco, and 1960 roots). A total of 40 rats were randomly divided into 4 groups labeled A, B, C and D and kept in a well-ventilated room.  Group A served as control and these rats were treated with distilled water. Rats in groups B, C, and D were treated with 3 different doses of the bitters (20, 30 and 40 mL/Kgbw) respectively. The drugs were administered once daily for 10 and 21days consecutively. Animals were sacrificed 24 h after the last treatment. Blood samples were collected into heparinized sample bottles for analysis. There was no significant difference in the serum urea concentration of the results obtained. Histology results indicated normal kidney tissue architecture, with the exception of G. Winco herbal bitters at a dose of 40 ml/kg at both 10 and 21 days of administration respectively which showed distorted kidney tissue. This study had demonstrated that the three herbal bitters have minimal negative side effects on kidney function of the experimental Wistar albino rats when used at moderate dose concentrations.